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| ID: |
18 |
| Geo Accession: |
GSE18 (GEO Site) |
| Title: |
Yeast Stress Response |
| Platform id: |
GPL51 GPL52 GPL53 GPL54 GPL55 GPL56 GPL57 GPL63 GPL64 |
| Sample id: |
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| Status: | Public on Feb 12 2002 |
| Submission date: | 2002-02-08 |
| Last update date: | 2013-01-18 |
| Pubmed id: | 11102521 |
| Summary: | We explored genomic expression patterns in the yeast Saccharomyces cerevisiae responding to diverse environmental transitions. DNA microarrays were used to measure changes in transcript levels over time for almost every yeast gene, as cells responded to temperature shocks, hydrogen peroxide, the superoxide-generating drug menadione, the sulfhydryl-oxidizing agent diamide, the disulfide-reducing agent dithiothreitol, hyper- and hypo-osmotic shock, amino acid starvation, nitrogen source depletion, and progression into stationary phase. A large set of genes (approximately 900) showed a similar drastic response to almost all of these environmental changes. Additional features of the genomic responses were specialized for specific conditions. Promoter analysis and subsequent characterization of the responses of mutant strains implicated the transcription factors Yap1p, as well as Msn2p and Msn4p, in mediating specific features of the transcriptional response, while the identification of novel sequence elements provided clues to novel regulators. Physiological themes in the genomic responses to specific environmental stresses provided insights into the effects of those stresses on the cell.
Study is described in more detail in Gasch AP et al.(2000) Mol Biol Cell 11:4241-57
Keywords: other
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| Type: | Expression profiling by array |
| Contributor: | A,P,Gasch; P,T,Spellman; C,M,Kao; O Carmel-Harel; M,B,Eisen; G Storz; D Botstein; P,O,Brown |
| Contact: | Name: Stanford Microarray Database; Email: array@genome.stanford.edu; Phone: 650-498-6012; Department: Stanford University, School of Medicine; Institute: Stanford Microarray Database (SMD); Address: 300 Pasteur Drive; City: Stanford; State: CA; Zip/postal_code: 94305; Country: USA; Web_link: http://genome-www5.stanford.ed .. |
| Ftp SOFT: | GSE18 SOFT |
| Ftp sMatrix: | GSE18 sMatrix |
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