# Meltzerlab GEO Microarray Tool - View GSE Details
 
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ID: 3
Geo Accession: GSE3 (GEO Site)
Title: Renal Cell Carcinoma Differential Expression
Platform id: GPL10 GPL9
Sample id:
Total 342 GSM
Status: Public on Jul 19 2001
Submission date: 2001-07-19
Last update date: 2012-02-23
Pubmed id: 11691851  
Summary: We investigated the changes in gene expression accompanying the development and progression of kidney cancer using 31,500 element complementary DNA arrays. We measured expression profiles for paired neoplastic and non-cancerous renal epithelium samples from 37 individuals. Using an experimental design optimized for factoring out technological and biological noise, and an adapted statistical test, we find 1738 differentially expressed cDNAs with an expected number of 6 false positives. Functional annotation of these genes provided views of the changes in the activities of specific biological pathways in renal cancer. Cell adhesion, signal transduction, and nucleotide metabolism were among the biological processes with a large proportion of genes overexpressed in renal cell carcinoma. Downregulated pathways in the kidney tumor cells included small molecule transport, ion homeostasis, and oxygen and radical metabolism. Our expression profiling data uncover gene expression changes shared with other epithelial tumors, as well as a unique signature for renal cell carcinoma. Expression data for the differentially expressed cDNAs are available in the web supplement (http://www.dkfz-heidelberg.de/ ..).
Keywords = renal clear cell carcinoma, kidney
Keywords: other
Type: Expression profiling by array
Contributor: Judith,M,Boer; Wolfgang Huber; Holger Sueltmann; Friederike Wilmer; Anja von Heydebreck; Stefan Haas; Bernhard Korn; Andreas Vente; Laszlo Fuzesi; Martin Vingron; Annemarie Poustka
Contact: Name: Wolfgang Huber; Email: w.huber@dkfz.de; Phone: +49-6221-424709; Fax: +49-6221-423470; Department: Molecular Genome Analysis; Institute: German Cancer Research Center; Address: Im Neuenheimer Feld 280; City: Heidelberg; Zip/postal_code: 69120; Country: Germany; Web_link: www.dkfz-heidelberg.de/abt0840
Web link: www.dkfz-heidelberg.de/abt0840/whuber/rcc
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