# Meltzerlab GEO Microarray Tool - View GSE Details
Meltzerlab | GEO Site Home | GSE-GPL-GSM | GPL | GSE | GSM | GDS | GDS Subset | sMatrix | Help

View GSE Details

Previous Record - Next Record - Jump to ID:
ID: 33
Geo Accession: GSE33 (GEO Site)
Title: E. coli response to MMC
Platform id: GPL102
Sample id:
Total 16 GSM
Status: Public on Feb 26 2002
Submission date: 2002-02-25
Last update date: 2012-02-23
Pubmed id: 11967071  
Summary: Changes in gene expression after treatment of E. coli cultures with mitomycin C were assessed using gene array technology. Unexpectedly, a large number of genes (nearly 30% of all genes) displayed significant changes in their expression level. Analysis and classification of expression profiles of the corresponding genes allowed us to assign this large number of genes into a dozen to two dozen small clusters of genes with similar expression profiles. This assignment allowed us to describe systematically the changes in the level of gene expression in response to DNA damage. Among the damage-induced genes more than a hundred are novel. From those genes involved in DNA metabolism that have not been previously shown to be induced by DNA damage, for example, the mutS gene involved in mismatch repair is especially noteworthy. In addition to the SOS response, we observed the induction of other stress response pathways such as those of oxidative stress and osmotic protection. Among the genes that are down-regulated in response to DNA damage are numerous protein biosynthesis genes. Analysis of the gene expression data highlighted the essential involvement of sigmaS regulated genes and the general stress response network in the response to DNA damage.
Keywords = DNA damage, recA, SOS
Keywords: other
Type: Expression profiling by array
Contributor: Pavel,P,Khil; R. Daniel Camerini-Otero
Contact: Name: Pavel,P,Khil; Email: pk94j@nih.gov; Phone: 301-496-4638; Fax: (301)-496-9878; Laboratory: Genetics and Biochemistry Branch; Department: ; Institute: NIDDK; Address: 5 Memorial Dr.; City: Bethesda; State: MD; Zip/postal_code: 20892; Country: USA
Ftp sMatrix: GSE33 sMatrix
Meltzerlab/GB/CCR/NCI/NIH @2008 Contact: e-mail
Powered by BxAF Search