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ID: 5
Geo Accession: GSE5 (GEO Site)
Title: Global profile of germline gene expression in C. elegans
Platform id: GPL14
Sample id:
Total 34 GSM
Status: Public on Jul 24 2001
Submission date: 2001-07-24
Last update date: 2012-02-23
Pubmed id: 11030340  
Summary: We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi-related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not.
This research has been described more fully in Reinke V et al.(2000) Mol Cell 6:605-16
Keywords: other
Type: Expression profiling by array
Contributor: V,,Reinke; H,E,Smith; J Nance; J Wang; C Van Doren; R Begley; S,J,Jones; E,B,Davis; S Scherer; S Ward; S,K,Kim
Contact: Name: Stanford Microarray Database; Email: array@genome.stanford.edu; Phone: 650-498-6012; Department: Stanford University, School of Medicine; Institute: Stanford Microarray Database (SMD); Address: 300 Pasteur Drive; City: Stanford; State: CA; Zip/postal_code: 94305; Country: USA; Web_link: http://genome-www5.stanford.ed ..
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